Exploration of Metabolic Dis dedicate: Glucose 6-phosphate dehydrogenase compulsion 1.0 Abstract Glucose 6-phosphate dehydrogenase deficiency, with oer four hundred million cases, is the most prevalent enzyme defect worldwide. higher(prenominal) frequencies are recorded in Africa, Asia and the Mediterranean. It has also been observed that up to decade per cent of Afri fuck American males have a conceal form of this deficiency. This distemper is caused by X cerebrate get mutation in the glucose 6-phosphate dehydrogenase gene resulting in light amounts of the enzyme glucose 6-phosphate dehydrogenase existence produced. This enzyme is involved in the production of NADPH for loss line lock away cells by way of the pentose phosphate pathway and increases the antioxidant status of interrupt tongue to tissues. A deficiency in the enzyme results in the oxidisation of red blood cell membranes trineing to reductiond lifetime of the cell and associated dis eases such as haemolytic anaemia, neonatal jaundice and kernicterus. The deficiency is most commonly asymptomatic but can be diagnosed according to the manifestations of the disease.
The causes of manifestations of this disease includes: The consumption of fava beans (which contain glycosides and phagocytosing granulocytes), keen bacterial or viral infections and medications such as Primaquine, phenazopyridine and methylene blue. Treatment is limited and thus prevention activities moldiness be undertaken to avoid manifestations. Avoidance of foods and medications containing agents likely to increase oxidation activities i s necessary. This disease is rarely fatal bu! t can lead to persistent impairment and thus must be prevented and monitored. futurity areas for developing regarding this area should be in the development of an accessible application tool for populations at risk. This could lead to a decrease in frequency of clinical manifestations of this disease. 2.0 Introduction With over 400 million diagnosed cases of Glucose 6-phosphate dehydrogenase (G6PD)...If you want to get a full essay, order it on our website: OrderCustomPaper.com
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